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High Throughput Automation of Synthetic DNA and RNA on Nanostructured Ceramic Films
October 20, 2022 @ 1:00 pm - 2:00 pm EDT
Fully synthetic oligonucleotides are critical in nearly all disciplines of modern biology and precision medicine. Synthetic Biology, cell-free DNA (cfDNA) diagnostics, mRNA vaccines, interference RNA cancer therapeutics, self-amplifying saRNA. Access to abundant, high quality synthetic DNA and RNA at gram scales overnight could be a game changer for the future of healthcare and personalized medicine 1) reducing the time for the discovery of safe and effective biologics, 2) significantly increasing the clinical Phase I pipeline success and 3) reaching profitability years in advanced to recover R&D costs.
Typical commercial offerings for 500 ng of a single lyophilized gene take from 5 to 15 business days and cost over $2500 to produce. For even partial combinatorial libraries of mRNA biologics this process can become time consuming and prohibitable expensive. We will discuss how the use of nano-structured ceramic films enables the synthesis of hundreds of DNA genes in gram quantities overnight. Furthermore, we will describe how these nano-structured ceramics can be manufactured without the use of expensive, currently highly backlogged, nanofabs through the use of conventional physical and chemical means.
Speaker: Mario Blanco, PhD, President & CEO
Bio: Dr. Blanco holds a PhD in Physical Chemistry from UCLA. After working in the chemical and software industry for 10 years he was recruited by Caltech and NASA/JPL as a Research Scientist (1993-2010) and Senior Manager. He has 14 granted patents and over 65 refereed science articles. 15+ years’ experience in three prior startups: Program Manager at Molecular Simulations (Sunnyvale, CA), CSO at Liox Power (Pasadena, CA), CEO at CeliacAid (Temple City, CA). He founded Nanopec Inc. in 2017 to enable Synthetic DNA full automation to protect, heal and rejuvenate the human body. Dr. Blanco was recently featured by AzBio as one of the most promising CEOs for the Biotech industry in Arizona and Nanopec recognized by The Flinn Foundation as a top 6 new startups. Under his leadership Nanopec has filed 5 patents and established national and international R&D collaborations with some of the largest DNA banks and CDMOs. He is known for a lifetime of mentoring young promising scientists, engineers and entrepreneurs.